De-epimerizing DyKAT of β-lactones generated by isothiourea-catalysed enantioselective [2 + 2] cycloaddition-Reference-Cited by-同舟云学术

De-epimerizing DyKAT of β-lactones generated by isothiourea-catalysed enantioselective [2 + 2] cycloaddition

Published:2024 Issue:23 Volume:15 Page:8896-8904
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Conboy Aífe¹,Goodfellow Alister S.¹^ORCID,Kasten Kevin¹^ORCID,Dunne Joanne¹,Cordes David B.¹^ORCID,Bühl Michael¹^ORCID,Smith Andrew D.¹^ORCID

Affiliation:

1. EaStCHEM, School of Chemistry, University of St Andrews, St Andrews, Fife, KY16 9ST, UK

Abstract

A dynamic kinetic asymmetric transformation that couples epimerisation with a hydrogen bond-assisted nucleophilic addition and stereodetermining ring-opening is investigated.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC01410C

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5. Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis

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