Insights into the antimicrobial properties of a cationic steroid and antibiofilm performance in PDMS-based coatings to potentially treat urinary infections

Author:

Neves Ana Rita12,Freitas-Silva Joana23,Durães Fernando12,Silva Elisabete R.45,Rodrigues Inês C.23,Mergulhão Filipe67,Gomes Marisa67,Teixeira-Santos Rita67,Bernardes André Maria8ORCID,Silva Renata8,Remião Fernando8,Pinto Eugénia29,da Costa Paulo Martins23,Sousa Emília12ORCID,Correia da Silva Marta12

Affiliation:

1. Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal

2. CIIMAR – Interdisciplinary Centre of Marine and Environmental Research, Terminal de Cruzeiros do Porto de Leixões, 4450-208, Matosinhos, Portugal

3. ICBAS – Institute of Biomedical Sciences Abel Salazar, Rua de Jorge Viterbo Ferreira 228, Porto, Portugal

4. BioISI – BioSystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisbon, Campo Grande, 1749-016 Lisboa, Portugal

5. CERENA – Centro de Recursos Naturais e Ambiente, Instituto Superior Técnico, University of Lisbon, Av. Rovisco Pais, 1, 1049-001, Lisboa, Portugal

6. LEPABE – Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal

7. ALiCE - Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal

8. UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal

9. Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal

Abstract

Currently, multidrug-resistant (MDR) infections are one of the most important threats, driving the search for new antimicrobial compounds.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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