Stereoselective synthesis and antiproliferative activity of <i>allo</i>-gibberic acid-based 1,3-aminoalcohol regioisomers-Reference-Cited by-同舟云学术

Stereoselective synthesis and antiproliferative activity of allo-gibberic acid-based 1,3-aminoalcohol regioisomers

Published:2024 Issue:3 Volume:15 Page:874-887
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Khdar Zein Alabdeen¹,Le Tam Minh¹²,Schelz Zsuzsanna³^ORCID,Zupkó István³,Szakonyi Zsolt¹^ORCID

Affiliation:

1. Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös utca 6, H-6720 Szeged, Hungary

2. HUN-REN–SZTE Stereochemistry Research Group, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary

3. Institute of Pharmacodynamics and Biopharmacy, University of Szeged, H-6720 Szeged, Hungary

Abstract

Starting from gibberellic acid (GA3), a library of allo-gibberic acid-based aminoalcohols was synthesised, and their antiproliferative effects were assayed by in vitro MTT method against a panel of human cancer cell lines (HeLa, SiHa, A2780, MCF-7, MDA-MB-231).

Funder

Hungarian Science Foundation

Nemzeti Kutatási, Fejlesztési és Innovaciós Alap

Szegedi Tudományegyetem

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00665D

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