Discovery of benzoheterocyclic-substituted amide derivatives as apoptosis signal-regulating kinase 1 (ASK1) inhibitors-Reference-Cited by-同舟云学术

Discovery of benzoheterocyclic-substituted amide derivatives as apoptosis signal-regulating kinase 1 (ASK1) inhibitors

Published:2024 Issue:3 Volume:15 Page:856-873
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Tang Lin¹²³^ORCID,Li Minxiong²,Bai Changlin²,Feng Xuejin²,Hu Haiyang²,Yao Yufen⁴,Li Baiqing⁵,Li Hongwei⁶,Qin Guohong⁶,Xi Ning⁷,Lv Genpin³,Zhang Lei¹^ORCID

Affiliation:

1. MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, P.R. China

2. Sunshine Lake Pharmaceutical Co., Ltd., Dongguan 523871, P.R. China

3. Shaoguan HEC Technology R & D Co., Ltd, Shaoguan 512000, P.R. China

4. Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, 510006 Guangzhou, P.R. China

5. Guangzhou National Laboratory, Guangzhou 510005, P.R. China

6. Guangdong Yuchuang Electronics Co., Ltd., Shaoguan 512721, P.R. China

7. Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, P.R. China

Abstract

Three series of benzoheterocyclic-substituted amide derivatives were designed and synthesized in this work, and compound 17a was discovered to be a novel potent inhibitor of ASK1 with good druggability.

Funder

State Key Laboratory of Anti-Infective Drug Development

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00663H

Reference33 articles.

1. Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

2. Therapeutic application of apoptosis signal-regulating kinase 1 inhibitors

3. Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-induced Apoptosis by the Mitochondria-dependent Caspase Activation

4. Physiological Roles of ASK1-Mediated Signal Transduction in Oxidative Stress- and Endoplasmic Reticulum Stress-Induced Apoptosis: Advanced Findings from ASK1 Knockout Mice

5. Pleiotropic properties of ASK1