A nanodrug to combat cisplatin-resistance by protecting cisplatin with p-sulfonatocalix[4]arene and regulating glutathione S-transferases with loaded 5-fluorouracil-Reference-Cited by-同舟云学术

A nanodrug to combat cisplatin-resistance by protecting cisplatin with p-sulfonatocalix[4]arene and regulating glutathione S-transferases with loaded 5-fluorouracil

Published:2019 Issue:50 Volume:55 Page:7199-7202
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Dai Xin¹²³⁴⁵,Zhou Xueying¹²³⁴,Liao Chunyan¹²³⁴,Yao Yongchao¹²³⁴^ORCID,Yu Yunlong¹²³⁴,Zhang Shiyong¹²³⁴^ORCID

Affiliation:

1. National Engineering Research Centre for Biomaterials, and College of Chemistry

2. Sichuan University

3. Chengdu 610064

4. China

5. Zunyi Medical and Pharmaceutical College

Abstract

A nanodrug that can effectively combat cisplatin-resistant A549/CDDP cells was developed by protecting cisplatin from glutathione (GSH) detoxification trough a host–guest interaction between cisplatin and p-sulfonatocalix[4]arene.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C9CC03012C

Reference29 articles.

1. The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

2. Monomeric cisplatin complexes with glutathione: Coordination modes and binding affinities

3. Special article the glutathione S-transferases: An update

4. Cancer nanomedicine: progress, challenges and opportunities

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