Recent asymmetric synthesis of natural products bearing an α-tertiary amine moiety via temporary chirality induction strategies

Author:

Jeon Hongjun1ORCID,Kim Jae Hyun2ORCID,Kim Sanghee3ORCID

Affiliation:

1. Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Republic of Korea

2. College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea

3. College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea

Abstract

This review highlights recent advances in the asymmetric synthesis of α-tertiary amine natural products via temporary chirality induction methods: Seebach's self-regeneration of stereocenters, C-to-N-to-C chirality transfer, and memory of chirality.

Funder

National Research Foundation of Korea

Korea Research Institute of Chemical Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference138 articles.

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3. A.Hameed , M.Al-Rashida and M. R.Shah , α-Tertiary Amines en Route to Natural Products , Elsevier , Amsterdam , 2021

4. Total Synthesis of Natural tert-Alkylamino Hydroxy Carboxylic Acids

5. Quaternary centres bearing nitrogen (α-tertiary amines) as products of molecular rearrangements

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