Diminazene or berenil, a classic duplex minor groove binder, binds to G-quadruplexes with low nanomolar dissociation constants and the amidine groups are also critical for G-quadruplex binding-Reference-Cited by-同舟云学术

Diminazene or berenil, a classic duplex minor groove binder, binds to G-quadruplexes with low nanomolar dissociation constants and the amidine groups are also critical for G-quadruplex binding

Published:2014 Issue:10 Volume:10 Page:2724-2734
ISSN:1742-206X
Container-title:Mol. BioSyst.
language:en
Short-container-title:Mol. BioSyst.

Author:

Zhou Jie¹²³,Le Vu⁴⁵⁶,Kalia Dimpy¹²³,Nakayama Shizuka¹²³,Mikek Clinton⁴⁵⁶,Lewis Edwin A.⁴⁵⁶,Sintim Herman O.¹²³⁷⁸

Affiliation:

1. Department of Chemistry and Biochemistry

2. University of Maryland

3. College Park, USA

4. Department of Chemistry

5. Mississippi State University

6. Mississippi State, USA

7. Program in Oncology

8. University of Maryland Marlene and Stewart Greenebaum Cancer Center

Abstract

Diminazene or berenil is known to be an AT-rich DNA minor groove binder with micromolar dissociation constant. Here, we show that DMZ binds to G-quadruplexes withK_das low as 1 nM.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MB/C4MB00359D

Reference77 articles.

1. HELIX FORMATION BY GUANYLIC ACID

2. DNA secondary structures: stability and function of G-quadruplex structures

3. An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translation

4. TRIPLEX DNA STRUCTURES

5. Formation of a stable triplex from a single DNA strand

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