Theoretical investigation on the reaction mechanism of UTP cyclohydrolase-Reference-Cited by-同舟云学术

Theoretical investigation on the reaction mechanism of UTP cyclohydrolase

Published:2022 Issue:29 Volume:24 Page:17641-17653
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Ouyang Qingwen¹^ORCID,Pang Yunjie¹,Yuan Chang¹,Tan Hongwei¹^ORCID,Li Xichen¹,Chen Guangju¹

Affiliation:

1. Key Laboratory of Theoretical and Computational Photochemistry, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China

Abstract

Between the two hydrolysis reactions catalyzed by UrcA, the reaction intermediate experiences conformation overturn with the assistance from Tyr307.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CP/D2CP01740G

Reference33 articles.

1. Degradation of purines and pyrimidines by microorganisms

2. Pyrimidine catabolism: individual characterization of the three sequential enzymes with a new assay

3. Oxidative catabolism of uracil byEnterobacter aerogenes

4. Barbiturase, a Novel Zinc-containing Amidohydrolase Involved in Oxidative Pyrimidine Metabolism

5. The Rut Pathway for Pyrimidine Degradation: Novel Chemistry and Toxicity Problems

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