Amyloid inhibition by molecular chaperones <i>in vitro</i> can be translated to Alzheimer's pathology <i>in vivo</i>-Reference-Cited by-同舟云学术

Amyloid inhibition by molecular chaperones in vitro can be translated to Alzheimer's pathology in vivo

Published:2023 Issue:5 Volume:14 Page:848-857
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Abelein Axel¹^ORCID,Johansson Jan¹

Affiliation:

1. Department of Biosciences and Nutrition, Karolinska Institutet, 141 83 Huddinge, Sweden

Abstract

Molecular chaperones are important components in the cellular quality-control machinery and increasing evidence points to potential new roles for them as suppressors of amyloid formation in neurodegenerative diseases, such as Alzheimers disease.

Funder

Svenska Forskningsrådet Formas

Svenska Sällskapet för Medicinsk Forskning

Hjärnfonden

Åke Wiberg Stiftelse

Magnus Bergvalls Stiftelse

Vetenskapsrådet

Center for Innovative Medicine

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00040K

Reference64 articles.

1. Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro

2. Intravenous treatment with a molecular chaperone designed against β-amyloid toxicity improves Alzheimer’s disease pathology in mouse models

3. Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue

4. A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

5. Amyloid-β oligomers are captured by the DNAJB6 chaperone: Direct detection of interactions that can prevent primary nucleation

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