Surface defection reduces cytotoxicity of Zn(2-methylimidazole)2 (ZIF-8) without compromising its drug delivery capacity

Author:

Shearier Emily123,Cheng Peifu423,Zhu Zhuan567,Bao Jiming567,Hu Yun Hang423,Zhao Feng123

Affiliation:

1. Department of Biomedical Engineering

2. Michigan Technological University

3. Houghton, USA

4. Department of Materials Science and Engineering

5. Department of Electrical & Computer Engineering

6. University of Houston

7. Houston, USA

Abstract

Surface defection incurs bond breakage and unsaturated Zn-sites and N-sites on the external surface of ZIF-8 particles. These bonds in turn bind H2O molecules in an aqueous environment, converting ZIF-8 from hydrophobic to hydrophilic.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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