The organocatalyzed domino Michael–aldol reaction revisited. Synthesis of enantioenriched 3-hydroxycyclohexanone derivatives by reaction of enals with α,α′-diaryl-substituted acetone-Reference-Cited by-同舟云学术

The organocatalyzed domino Michael–aldol reaction revisited. Synthesis of enantioenriched 3-hydroxycyclohexanone derivatives by reaction of enals with α,α′-diaryl-substituted acetone

Published:2015 Issue:81 Volume:5 Page:65975-65981
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Guevara-Pulido James O.¹²³⁴⁵,Andrés José M.¹²³⁴⁵,Pedrosa Rafael¹²³⁴⁵

Affiliation:

1. Instituto CINQUIMA and Departamento de Química Orgánica

2. Facultad de Ciencias

3. Universidad de Valladolid

4. 47011-Valladolid

5. Spain

Abstract

The reaction of enals with α,α′-diaryl-substituted acetones (pK_a > 18) catalyzed by (S)-1-(2-pyrrolidinylmethyl) pyrrolidine provides direct access to enantioenriched 2,5,6-trisubstituted-3-hydroxy cyclohexanones.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA11215J

Reference37 articles.

1. Enantioselective Organocatalyzed Domino Synthesis of Six-Membered Carbocycles

2. Recent Developments in Asymmetric Organocatalytic Domino Reactions

3. Asymmetric Organocatalytic Cyclization and Cycloaddition Reactions

4. Organocatalytic Enantioselective Michael and Hetero-Michael Reactions

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