Facile folding of insulin variants bearing a prosthetic C-peptide prepared by α-ketoacid-hydroxylamine (KAHA) ligation
Author:
Affiliation:
1. Laboratorium für Organische Chemie
2. Department of Chemistry and Applied Biosciences
3. ETH Zürich
4. 8093 Zürich
5. Switzerland
6. Sanofi-Aventis Deutschland GmbH Industriepark Hoechst
7. 65926 Frankfurt am Main
8. Germany
Abstract
Ester forming KAHA-ligation and a traceless prosthetic C-peptide provides a modular platform for the synthesis and folding of insulin variants.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/SC/C8SC03738H
Reference29 articles.
1. Insulin structure and function
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4. A Synthetic Route to Human Insulin Using Isoacyl Peptides
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