Specificity of SNP detection with molecular beacons is improved by stem and loop separation with spacers-Reference-Cited by-同舟云学术

Specificity of SNP detection with molecular beacons is improved by stem and loop separation with spacers

Published:2017 Issue:6 Volume:142 Page:945-950
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Farzan Valentina M.¹²³⁴⁵,Markelov Mikhail L.⁶⁷⁵,Skoblov Alexander Yu.⁸⁹¹⁰,Shipulin German A.¹¹¹²⁵,Zatsepin Timofei S.¹²³⁴⁵^ORCID

Affiliation:

1. Skolkovo Institute of Science and Technology

2. 3 Nobel Street

3. Innovation Center “Skolkovo”

4. 143026 Skolkovo

5. Russia

6. Research Institute of Occupational Health

7. 105275 Moscow

8. Metkinen Chemistry Oy.

9. FI-70210 Kuopio

10. Finland

11. Central Research Institute of Epidemiology

12. 111123 Moscow

Abstract

Dissection of stem and loop regions in molecular beacons by nucleotide or non-nucleotide linkers minimizes nonspecific recognition in SNP discrimination.

Funder

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/AN/C6AN02441F

Reference45 articles.

1. Molecular Engineering of DNA: Molecular Beacons

2. Molecular beacons: An optimal multifunctional biological probe

3. Recent trends in molecular beacon design and applications

4. Oligonucleotide optical switches for intracellular sensing

5. In situ single step detection of exosome microRNA using molecular beacon

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