NIR-II imaging-guided diagnosis and evaluation of the therapeutic effect on acute alcoholic liver injury via a nanoprobe

Author:

Nie Gang1,Zhou Yinxing1,Song Mengzi1,Xu Jingya1,Cui Zheng2,Feng Yangzhen3,Wang Huiling4,Chen Dugang3ORCID,Zhang Yu2ORCID,Wang Kaiping1ORCID

Affiliation:

1. Hubei Key Laboratory of Nature Medicinal Chemistry and Resource Evaluation, Tongji Medical College of Pharmacy, Huazhong University of Science and Technology, Wuhan, China

2. Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

3. Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, China

4. Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Chemical Biology Center, College of Chemistry, International Joint Research Center for Intelligent Biosensing Technology and Health, Central China Normal University, Wuhan, China

Abstract

A NIR-II nanoprobe was developed and applied with excellent photostability and prominent biocompatibility to diagnose acute alcoholic liver injury in mice in vivo and evaluate the therapeutic effects of a drug on AALI mice by NIR-II imaging.

Funder

National Natural Science Foundation of China

Hubei Provincial Department of Education

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

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