Sterol sulfate alleviates atherosclerosis via mediating hepatic cholesterol metabolism in ApoE−/− mice

Author:

Ding Lin1234,Xu Zhen-Jing1234,Shi Hao-Hao1234,Xue Chang-Hu12345,Huang Qing-Rong678910ORCID,Yanagita Teruyoshi1112131415,Wang Yu-Ming12345ORCID,Zhang Tian-Tian1234ORCID

Affiliation:

1. College of Food Science and Engineering

2. Ocean University of China

3. Qingdao

4. China

5. Laboratory of Marine Drugs and Bioproducts

6. Rutgers

7. The State University of New Jersey

8. Department of Food Science

9. New Brunswick

10. USA

11. Laboratory of Nutrition Biochemistry

12. Department of Applied Biochemistry and Food Science

13. Saga University

14. Saga 8408502

15. Japan

Abstract

Sterol sulfate (SCS) supplementation ameliorates atherosclerosis via decreasing cholesterol levels. Mechanistically, SCS increases cholesterol uptake by hepatocytes, decreases cholesterol synthesis, and regulates bile acid metabolism in the liver.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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