Acid-sensitive PEG-removable nanoscale liposomes for delivery of doxorubicin in A549/ADR therapy

Author:

Chen Hailiang1,Liu Chenyu1,Yu Simiao1,Zhou Hengjun1,Shafiq Farishta1,Qiao Weihong1ORCID

Affiliation:

1. State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, P. R. China

Abstract

Acid-sensitive PEG-removable mPEG-NCH-DOB was prepared for modification of liposomes PHDGX to overcome the “PEG dilemma”. PHDGX can accelerate the release of DOX in acidic media and overcome the DOX resistance of A549/ADR at low DOX concentrations.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Doctoral Start-up Foundation of Liaoning Province

Dalian Science and Technology Innovation Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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