Intrinsic acetamide brush-off by polyurea biodendrimers
Author:
Affiliation:
1. Institute for Bioengineering and Biosciences
2. Instituto Superior Técnico
3. Universidade de Lisboa
4. Lisboa
5. Portugal
6. School of Life and Medical Sciences
7. University of Hertfordshire
8. Hatfield
9. UK
10. Faculty of Pharmacy
Abstract
Polyurea biodendrimers display an intrinsic affinity–repulsion ability towards drug–acetamide mixtures, turning these nanocarriers into an attractive platform for API purification and/or preparation of genotoxin-free nanoformulations.
Funder
Fundação para a Ciência e a Tecnologia
Publisher
Royal Society of Chemistry (RSC)
Subject
General Materials Science,Biomedical Engineering,General Chemistry,General Medicine
Link
http://pubs.rsc.org/en/content/articlepdf/2021/TB/D1TB00105A
Reference32 articles.
1. Organic solvent nanofiltration: A platform for removal of genotoxins from active pharmaceutical ingredients
2. Monitoring and Control of Genotoxic Impurity Acetamide in the Synthesis of Zaurategrast Sulfate
3. Green Development of Polymeric Dummy Artificial Receptors with Affinity for Amide-Based Pharmaceutical Impurities
4. Drug complexation, in vitro release and cellular entry of dendrimers and hyperbranched polymers
5. Association of a Weakly Acidic Anti-Inflammatory Drug (Ibuprofen) with a Poly(Amidoamine) Dendrimer as Studied by Molecular Dynamics Simulations
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