A two-step binding mechanism for the self-binding peptide recognition of target domains-Reference-Cited by-同舟云学术

A two-step binding mechanism for the self-binding peptide recognition of target domains

Published:2016 Issue:4 Volume:12 Page:1201-1213
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Yang Chao¹²³⁴⁵,Zhang Shilei¹²³⁴⁵,Bai Zhengya¹²³⁴⁵,Hou Shasha¹²³⁴⁵,Wu Di¹²³⁴⁵,Huang Jian¹²³⁴⁵,Zhou Peng¹²³⁴⁵

Affiliation:

1. Center of Bioinformatics (COBI)

2. School of Life Science and Technology

3. University of Electronic Science and Technology of China (UESTC)

4. Chengdu 610054

5. China

Abstract

By using state-of-the-art molecular dynamics to reconstruct the complete structural dynamics picture of self-binding peptides, a two-step binding mechanism was proposed, including a fast, nonspecific diffusive phase and a slow, specific organizational phase.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MB/C5MB00800J

Reference52 articles.

1. A Dynamic View of Domain-Motif Interactions

2. Systematic Discovery of New Recognition Peptides Mediating Protein Interaction Networks

3. Peptides mediating interaction networks: new leads at last