A two-step binding mechanism for the self-binding peptide recognition of target domains
Author:
Affiliation:
1. Center of Bioinformatics (COBI)
2. School of Life Science and Technology
3. University of Electronic Science and Technology of China (UESTC)
4. Chengdu 610054
5. China
Abstract
By using state-of-the-art molecular dynamics to reconstruct the complete structural dynamics picture of self-binding peptides, a two-step binding mechanism was proposed, including a fast, nonspecific diffusive phase and a slow, specific organizational phase.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
Molecular Biology,Biotechnology
Link
http://pubs.rsc.org/en/content/articlepdf/2016/MB/C5MB00800J
Reference52 articles.
1. A Dynamic View of Domain-Motif Interactions
2. Systematic Discovery of New Recognition Peptides Mediating Protein Interaction Networks
3. Peptides mediating interaction networks: new leads at last
4. Peptide-mediated interactions in biological systems: new discoveries and applications
5. Targeting protein–protein interactions by rational design: mimicry of protein surfaces
Cited by 110 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Computational Analysis and Rational Design of N-Substituting Perturbation on the Affinity and Specificity of Pediatric Fyn SH3–Peptoid Interaction;Journal of Computational Biophysics and Chemistry;2023-07-26
2. Rational design of stapled helical peptides as antidiabetic PPARγ antagonists to target coactivator site by decreasing unfavorable entropy penalty instead of increasing favorable enthalpy contribution;European Biophysics Journal;2022-09-04
3. Rational truncation, mutation, and halogenation of bradykinin neuropeptides as potent ACEII inhibitors by integrating molecular dynamics simulations, quantum mechanics calculations, and in vitro assays;Journal of the Chinese Chemical Society;2022-07-22
4. Interleukin‐1α, interleukin‐1β and interleukin‐1 receptor antagonist share a common U‐shaped recognition epitope on interleukin‐1 receptor surface;Journal of Molecular Recognition;2022-05-29
5. Integrated unsupervised–supervised modeling and prediction of protein–peptide affinities at structural level;Briefings in Bioinformatics;2022-03-29
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3