20(<i>S</i>)-Protopanaxadiol decreases atherosclerosis in ApoE KO mice by increasing the levels of LDLR and inhibiting its binding with PCSK9-Reference-Cited by-同舟云学术

20(S)-Protopanaxadiol decreases atherosclerosis in ApoE KO mice by increasing the levels of LDLR and inhibiting its binding with PCSK9

Published:2022 Issue:13 Volume:13 Page:7020-7028
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Huang Ye-Wei¹²^ORCID,Zhang Meng¹³,Wang Li-Tian¹³,Nie Yan¹³,Yang Jin-Bo¹³,Meng Wen-Luer¹³,Wang Xuan-jun¹²,Sheng Jun¹⁴

Affiliation:

1. Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, 650201, China

2. College of Science, Yunnan Agricultural University, Kunming, 650201, China

3. College of Food Science and Technology, Yunnan Agricultural University, Kunming, 650201, China

4. State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Kunming, 650201, China

Abstract

Our results demonstrate that PPD directly binds to the extracellular domain of LDLR and inhibits the interaction between PCSK9 and LDLR, thereby increasing the levels of LDLR and alleviating atherosclerosis in HFD-fed ApoE KO mice.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D2FO00392A

Reference46 articles.

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2. LDL cholesterol targets – how low to go?

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4. The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9

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