Ulcerative colitis alleviation of colon-specific delivered rhamnolipid/fullerene nanocomposites via dual modulation in oxidative stress and intestinal microbiome

Author:

Xia Yuxuan1,Hong Liu1ORCID,Zheng Jiayao1,Lu Ziyi1,Zhang Qiong1,Chen Siyu1,Pang Zhi23,Li Lei4,Qiao Shumiao5,Wang Qiang5,Zhou Yonghua5,Yang Cheng1

Affiliation:

1. Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China

2. Department of Digestive Disease and Nutrition Research Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215008, China

3. Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215008, China

4. Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China

5. Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control, Jiangsu Institute of Parasitic Diseases and Public Health Research Center of Jiangnan University, Wuxi 214064, China

Abstract

Ulcerative colitis inflammation is profoundly alleviated by colon-targeting delivery of low dose (0.4 mg kg−1) rhamnolipid/fullerene nanocomposites via the synergism of oxidative stress mitigation and gut microbiome recovery.

Funder

Natural Science Foundation of Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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