The role of chemical synthesis in developing RiPP antibiotics-Reference-Cited by-同舟云学术

The role of chemical synthesis in developing RiPP antibiotics

Published:2021 Issue:7 Volume:50 Page:4245-4258
ISSN:0306-0012
Container-title:Chemical Society Reviews
language:en
Short-container-title:Chem. Soc. Rev.

Author:

Rowe Sam M.¹²³⁴^ORCID,Spring David R.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Cambridge

3. Cambridge

4. UK

Abstract

This tutorial review discusses the potential of ribosomally synthesised and post-translationally modified peptides (RiPPs) as antimicrobials and looks at the chemical synthesis of three classes of RiPP: lasso peptides, cyclotides, and lanthipeptides.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CS/D0CS01386B

Reference50 articles.

1. J. O’Neill , Tackling Drug-Resistant Infections Globally: Final Report and Recommendations , 2016

2. RiPP antibiotics: biosynthesis and engineering potential

3. New developments in RiPP discovery, enzymology and engineering

4. Novel Antimicrobials for the Treatment of Clostridium difficile Infection

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