Design, synthesis and biological evaluation of 1-phenanthryl-tetrahydroisoquinoline derivatives as novel p21-activated kinase 4 (PAK4) inhibitors-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of 1-phenanthryl-tetrahydroisoquinoline derivatives as novel p21-activated kinase 4 (PAK4) inhibitors

Published:2015 Issue:12 Volume:13 Page:3803-3818
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Song Shuai¹²³⁴,Li Xiaodong⁵⁶⁷⁸⁹,Guo Jing¹²³⁴,Hao Chenzhou¹²³⁴,Feng Yan¹²³⁴,Guo Bingyu⁵⁶⁷⁸⁹,Liu Tongchao¹²³⁴,Zhang Qiaoling¹²³⁴,Zhang Zhen¹²³⁴,Li Ruijuan¹²³⁴,Wang Jian¹²³⁴,Lin Bin¹²³⁴,Li Feng⁵⁶⁷⁸⁹,Zhao Dongmei¹²³⁴,Cheng Maosheng¹²³⁴

Affiliation:

1. Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education

2. Shenyang Pharmaceutical University

3. Shenyang 110016

4. P. R. China

5. Department of Cell Biology

6. Key Laboratory of Cell Biology

7. Ministry of Public Health

8. and Key Laboratory of Medical Cell Biology

9. Ministry of Education

Abstract

Following the screening of an in-house natural product database, 1-phenanthryltetrahydroisoquinoline analogues were synthesized as novel PAK4 inhibitors.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00037H

Reference38 articles.

1. A brain serine/threonine protein kinase activated by Cdc42 and Rac1

2. p21-Activated protein kinase: a crucial component of morphological signaling?

3. The emerging importance of group II PAKs

4. Biology of the p21-Activated Kinases

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