Stereogenic α-carbons determine the shape and topology of [13]-macrodilactones-Reference-Cited by-同舟云学术

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Stereogenic α-carbons determine the shape and topology of [13]-macrodilactones

Published:2015 Issue:18 Volume:13 Page:5086-5089
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Magpusao Anniefer N.¹²³⁴,Rutledge Kelli¹²³⁴,Mercado Brandon Q.¹⁵⁶⁴,Peczuh Mark W.¹²³⁴

Affiliation:

1. Department of Chemistry

2. University of Connecticut

3. Storrs

4. USA

5. Yale University

6. New Haven

Abstract

The configuration of α-stereogenic centers affects the shape and topology of [13]-macrodilactones. When one α-stereogenic center is substituted, it directs the planar chirality of the macrocycle; when two centers are substituted, both the shape and the topology are influenced.

Funder

Division of Chemistry

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00402K

Reference35 articles.

1. Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model

2. Planar Chirality of Imidazole-Containing Macrocycles - Understanding and Tuning Atropisomerism

3. How proteins bind macrocycles

4. The exploration of macrocycles for drug discovery — an underexploited structural class

5. Macrocycles in new drug discovery

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3. Exploring the physicochemical and antiproliferative properties of biaryl-linked [13]-macrodilactones;Bioorganic & Medicinal Chemistry;2020-10

4. Structures of three disubstituted [13]-macrodilactones reveal effects of substitution on macrocycle conformation;Acta Crystallographica Section E Crystallographic Communications;2020-09-08

5. Protecting-group-free synthesis of hydroxyesters from amino alcohols;Chemical Communications;2020

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