Changing stereoselectivity and regioselectivity in copper(i)-catalyzed 5-exo cyclization by chelation and rigidity in aminoalkyl radicals: synthesis towards diverse bioactive N-heterocycles
Author:
Affiliation:
1. Department of Chemistry
2. Amrita Vishwa Vidyapeetham
3. Amritapuri
4. India
5. Indian Institute of Technology
Abstract
Chelation, rigidity and carbon-radical positions in aminoalkyl precursors disturb the usual 2,4-trans diastereoselectivity and 5-exo mode in Cu(i)-catalyzed ATRC.
Funder
Council of Scientific and Industrial Research, India
Publisher
Royal Society of Chemistry (RSC)
Subject
Materials Chemistry,General Chemistry,Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2020/NJ/C9NJ05166J
Reference96 articles.
1. Finding the right path: Baldwin “Rules for Ring Closure” and stereoelectronic control of cyclizations
2. Guidelines for radical reactions: some thirty years on
3. Controlling Regioselectivity in Cyclization of Unsaturated Amidyl Radicals: 5-Exo Versus 6-Endo
4. Theoretical Elucidation of Kinetic and Thermodynamic Control of Radical Addition Regioselectivity
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