Enzyme-instructed self-assembly of a novel histone deacetylase inhibitor with enhanced selectivity and anticancer efficiency-Reference-Cited by-同舟云学术

Enzyme-instructed self-assembly of a novel histone deacetylase inhibitor with enhanced selectivity and anticancer efficiency

Published:2019 Issue:4 Volume:7 Page:1477-1485
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Gao Yang¹²³⁴⁵,Zhang Congrou¹²³⁴⁵,Chang Jinglin¹²³⁴⁵,Yang Cuihong¹²³⁴⁵^ORCID,Liu Jianfeng¹²³⁴⁵,Fan Saijun¹²³⁴⁵,Ren Chunhua¹²³⁴⁵^ORCID

Affiliation:

1. Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine

2. Institute of Radiation Medicine

3. Chinese Academy of Medical Sciences and Peking Union Medical College

4. Tianjin

5. China

Abstract

A novel peptide-based prodrug molecule could be activated in situ via ALP catalysis and further self-assembled into a nanodrug with enhanced selectivity and anticancer efficacy.

Funder

National Natural Science Foundation of China

Peking Union Medical College

Chinese Academy of Medical Sciences

Natural Science Foundation of Tianjin City

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2019/BM/C8BM01422A

Reference50 articles.

1. Pharmacokinetics of metronomic chemotherapy: a neglected but crucial aspect

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