Design and synthesis of fluorescent 7-deazaadenosine nucleosides containing π-extended diarylacetylene motifs

Author:

De Ornellas Sara12345ORCID,Slattery John M.1234,Edkins Robert M.1674,Beeby Andrew1674,Baumann Christoph G.52348,Fairlamb Ian J. S.12348

Affiliation:

1. Department of Chemistry

2. University of York

3. York

4. UK

5. Department of Biology

6. University of Durham

7. Durham

8. Biological Physical Sciences Institute (BPSI)

Abstract

A novel series of C-modified π-extended 7-deazaadenosines exhibit promising fluorescence properties.

Funder

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference20 articles.

1. C. R. Cremo , in Methods in Enzymology, ed. I. P. Gerard Marriott, Academic Press, 2003, vol. 360, pp. 128–177

2. D. M. Jameson and J. F.Eccleston, in Methods in Enzymology, ed. M. L. J. Ludwig Brand, Academic Press, 1997, vol. 278, pp. 363–390

3. Sonogashira alkynylation of unprotected 8-brominated adenosines and guanosines: fluorescence properties of compact conjugated acetylenes containing a purine ring

4. A sequential direct arylation/Suzuki–Miyaura cross-coupling transformation of unprotected 2′-deoxyadenosine affords a novel class of fluorescent analogues

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