Efficient mRNA delivery using lipid nanoparticles modified with fusogenic coiled-coil peptides-Reference-Cited by-同舟云学术

Efficient mRNA delivery using lipid nanoparticles modified with fusogenic coiled-coil peptides

Published:2023 Issue:37 Volume:15 Page:15206-15218
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Zeng Ye¹,Shen Mengjie¹,Pattipeiluhu Roy¹,Zhou Xuequan¹,Zhang Yun¹,Bakkum Thomas¹,Sharp Thomas H.²,Boyle Aimee L.¹^ORCID,Kros Alexander¹^ORCID

Affiliation:

1. Department of Supramolecular & Biomaterials Chemistry, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands

2. Department of Cell and Chemical Biology, Section Electron Microscopy, Leiden University Medical Center, 2300 RC Leiden, The Netherlands

Abstract

Regular nanoparticles delivery efficiency is hindered by endosome entrapment. By modifying lipid-nanoparticles with lipopeptide CPE4 and pretreating the cells with complimentary CPK4, coiled-coil peptides induced significantly enhanced mRNA delivery in various cell lines mediated by membrane fusion.

Funder

China Sponsorship Council

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NR/D3NR02175K

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