Metal-free radical C–H methylation of pyrimidinones and pyridinones with dicumyl peroxide-Reference-Cited by-同舟云学术

Metal-free radical C–H methylation of pyrimidinones and pyridinones with dicumyl peroxide

Published:2017 Issue:4 Volume:19 Page:919-923
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Zhang Pei-Zhi¹²³⁴⁵,Li Jian-An¹²³⁴⁵,Zhang Ling¹²³⁴⁵,Shoberu Adedamola¹²³⁴⁵,Zou Jian-Ping¹²³⁴⁵^ORCID,Zhang Wei⁶⁷⁸⁹^ORCID

Affiliation:

1. Key Laboratory of Organic Synthesis of Jiangsu Province

2. College of Chemistry and Chemical Engineering

3. Soochow University

4. Suzhou

5. China

6. Centre for Green Chemistry and Department of Chemistry

7. University of Massachusetts Boston

8. Boston

9. USA

Abstract

A method for free radical methylation of pyrimidinones and pyridinones with dicumyl peroxide under metal-free conditions is introduced. A 50 g-scale reaction could be performed safely. The product was separated by crystallization and the byproducts were recovery by distillation.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/GC/C6GC03355E

Reference64 articles.

1. Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions

2. The Methylation Effect in Medicinal Chemistry

3. Iron-Catalyzed Directed C(sp2)–H and C(sp3)–H Functionalization with Trimethylaluminum

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