Differentiation state and culture conditions impact neural stem/progenitor cell-derived extracellular vesicle bioactivity-Reference-Cited by-同舟云学术

Differentiation state and culture conditions impact neural stem/progenitor cell-derived extracellular vesicle bioactivity

Published:2023 Issue:16 Volume:11 Page:5474-5489
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Dutta Dipankar¹,Pirolli Nicholas H.¹,Levy Daniel¹,Tsao Jeffrey¹,Seecharan Nicholas¹,Wang Zihui²,Xu Xiang²,Jia Xiaofeng²³^ORCID,Jay Steven M.¹⁴^ORCID

Affiliation:

1. Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA

2. Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA

3. Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA

4. Program in Molecular and Cell Biology, University of Maryland, College Park, MD, USA

Abstract

Extracellular vesicles (EVs) purified from neural progenitor/stem cells (NPSCs) cultured with a rationally-selected ECM type (fibronectin) and growth factor (nerve growth factor (NGF)) enhanced nerve regeneration and muscle recovery in a rat sciatic nerve crush injury model.

Funder

National Institutes of Health

University of Maryland

Maryland Stem Cell Research Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/BM/D3BM00340J

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4. Human Neural Stem Cell Extracellular Vesicles Improve Recovery in a Porcine Model of Ischemic Stroke

5. Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model