Seeded droplet microfluidic system for small molecule crystallization-Reference-Cited by-同舟云学术

Seeded droplet microfluidic system for small molecule crystallization

Published:2020 Issue:10 Volume:20 Page:1815-1826
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Garg N.¹²³⁴⁵^ORCID,Tona R.¹²³⁴⁵^ORCID,Martin P.⁶²⁷⁴^ORCID,Martin-Soladana P. M.¹²⁸⁹,Ward G.¹²⁸⁹,Douillet N.¹²⁸⁹,Lai D.¹²³⁴⁵

Affiliation:

1. Advanced Manufacturing Technologies

2. GlaxoSmithKline

3. King of Prussia

4. USA

5. Product and Process Engineering

6. Biopharmaceutical Product Development and Supply

7. Collegeville

8. Stevenage

9. UK

Abstract

A microfluidic approach to seeded crystallization has been demonstrated using abacavir hemisulfate, a nucleoside analog reverse transcriptase inhibitor, in droplet reactors to control polymorphism and produce particles with a low particle size distribution.

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/LC/D0LC00122H

Reference33 articles.

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2. R. McKeown , L.Derdour , P.Dell'Orco and J.Wertman CRYSTALLIZATION DESIGN AND SCALE-UP, in Chemical Engineering in the Pharmaceutical Industry , ed. D. J. Am Ende and M. T. Am Ende , John Wiley & Sons, Inc. , 2019 , pp. 533–567 , 10.1002/9781119600800.ch24

3. Modification of Crystal Habit and Its Role in Dosage Form Performance

4. Recent developments in scale-up of microfluidic emulsion generation via parallelization

5. The price of innovation: new estimates of drug development costs

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