Membrane phosphatidylserine allosterically regulates the cytosolic phospholipase A2 activity <i>via</i> an electrostatic-switch mechanism-Reference-Cited by-同舟云学术

Membrane phosphatidylserine allosterically regulates the cytosolic phospholipase A2 activity via an electrostatic-switch mechanism

Published:2022 Issue:11 Volume:18 Page:2203-2210
ISSN:1744-683X
Container-title:Soft Matter
language:en
Short-container-title:Soft Matter

Author:

Geng Feng¹²^ORCID,Zhang Guangxu²³⁴⁵,Wang Yadi¹²,Lü Junhong¹²³⁴^ORCID

Affiliation:

1. School of Pharmacy, Binzhou Medical University, Yantai 264003, China

2. Jinan Microecological Biomedicine Shandong Laboratory, Jinan 250000, China

3. CAS key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China

4. Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201203, China

5. University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

Experimental and theoretical approaches suggest an electrostatic-switch allosteric mechanism for cytosolic phospholipase A2 activation on the cell membrane interface under the inflammatory state.

Funder

Key Research Program of Frontier Science, Chinese Academy of Sciences

Natural Science Foundation of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SM/D1SM01791H

Reference35 articles.

1. Phospholipase A2 Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

2. Regulatory Functions of Phospholipase A2

3. Review of four major distinct types of human phospholipase A2

4. Phospholipase A2 at the bilayer interface

5. Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substrates

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