An in vitro method for nephrotoxicity evaluation using HK-2 human kidney epithelial cells combined with biomarkers of nephrotoxicity
Author:
Affiliation:
1. Chinese Academy of Medical Sciences & Peking Union Medical College
2. Beijing 100730
3. China
4. National Center for Safety Evaluation of Drugs
5. National Institutes for Food and Drug Control
6. Beijing 100176
Abstract
The HK-2 cell model based on clusterin, osteopontin, CysC and KIM-1 would allow the prediction of nephrotoxicity at early stages.
Funder
National Natural Science Foundation of China
Ministry of Science and Technology of the People's Republic of China
Publisher
Oxford University Press (OUP)
Subject
Health, Toxicology and Mutagenesis,Toxicology
Link
http://pubs.rsc.org/en/content/articlepdf/2018/TX/C8TX00095F
Reference29 articles.
1. Drug-associated renal dysfunction and injury
2. Acute kidney injury—epidemiology, outcomes and economics
3. Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1)
4. Acute kidney injury associated with the use of traditional medicines
5. Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
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