Simultaneous label-free screening of G-quadruplex active ligands from natural medicine via a microfluidic chip electrophoresis-based energy transfer multi-biosensor strategy
Author:
Affiliation:
1. School of Life Science
2. Beijing Institute of Technology
3. Beijing 100081
4. P.R. China
5. National Institute of Metrology
6. Beijing 100029
7. School of Chemical Engineering & environment
8. P. R. China
Abstract
Chip-electrophoresis-based separation was combined with an RET optical sensor to establish a new sense of a simultaneous label-free multi-drug screening method.
Publisher
Royal Society of Chemistry (RSC)
Subject
Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/AN/C7AN00692F
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1. Structure of the Human Telomere in K+ Solution: An Intramolecular (3 + 1) G-Quadruplex Scaffold
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3. G-quadruplex-mediated regulation of telomere binding protein POT1 gene expression
4. Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay
5. Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
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