Diaminocyclopentane-derived <i>O</i>-GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer's disease-Reference-Cited by-同舟云学术

Diaminocyclopentane-derived O-GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer's disease

Published:2022 Issue:63 Volume:58 Page:8838-8841
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Weber Patrick¹^ORCID,Mészáros Zuzana²³^ORCID,Jagečić Denis⁴^ORCID,Hribljan Valentina⁴^ORCID,Mitrečić Dinko⁴^ORCID,Bojarová Pavla²^ORCID,Slámová Kristýna²^ORCID,Vrba Jiří⁵^ORCID,Kulik Natalia²^ORCID,Křen Vladimír²^ORCID,Stütz Arnold E.¹^ORCID

Affiliation:

1. Glycogroup, Institute of Chemistry and Technology of Biobased Systems, Graz University of Technology, Stremayrgasse 9, A-8010, Graz, Austria

2. Laboratory of Biotransformation, Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-14220, Praha 4, Czech Republic

3. Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Technická 1903/3, CZ-16628, Praha 6, Czech Republic

4. Laboratory for Stem Cells, Croatian Institute for Brain Research, University of Zagreb School of Medicine, Šalata 3, HR-10000, Zagreb, Croatia

5. Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, CZ-77515, Olomouc, Czech Republic

Abstract

We report the synthesis and testing of a novel type (new lead structure) of powerful and highly selective human O-N-acetyl-β-d-glucosaminidase (enzyme associated with Alzheimer's disease) inhibitors that are not based on transition state mimetics.

Funder

Austrian Science Fund

European Regional Development Fund

Grantová Agentura České Republiky

Hrvatska Zaklada za Znanost

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC02712G

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