Asymmetric cross- and self-aldol reactions of aldehydes in water with a polystyrene-supported triazolylproline organocatalyst

Author:

Llanes Patricia1234,Sayalero Sonia1234,Rodríguez-Escrich Carles1234,Pericàs Miquel A.12345

Affiliation:

1. Institute of Chemical Research of Catalonia (ICIQ)

2. The Barcelona Institute of Science and Technology

3. 43007 Tarragona

4. Spain

5. Departament de Química Orgànica

Abstract

A PS-immobilized triazolylproline prepared by co-polymerization with full regiocontrol swells in water and catalyzes the enantioselective cross-aldol reaction and the self-aldol reaction of aldehydes under essentially neat conditions with excellent stereocontrol.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Reference64 articles.

1. Modern Aldol Reactions, ed. R. Mahrwald, Wiley-VCH, Weinheim, 2004, vol. 1 and 2

2. The direct catalytic asymmetric aldol reaction

3. Enantioselective organocatalytic aldol reaction using small organic molecules

4. G. Guillena , in Modern Methods in Stereoselective Aldol Reactions, ed. R. Mahrwald, Wiley-VCH, 2013, pp. 155–268

5. Catalytic asymmetric aldol reactions in aqueous media – a 5 year update

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