Synthesis of biologically active fused 1,4-oxathiin derivatives from 4-hydroxydithiocoumarins, arylacetylenes and dimethyl sulfoxide by Cu(i)-catalyzed C–H functionalization and cross-dehydrogenative C–S coupling reactions

Abstract

Novel synthesis of fused 1,4-oxathiin derivatives is reported via a pseudo-three component reaction, where DMSO acts as an oxygen donor and a solvent, and some of them exhibited anti-cancer activities.