Antibody-targeting of ultra-small nanoparticles enhances imaging sensitivity and enables longitudinal tracking of multiple myeloma

Author:

Detappe Alexandre12345ORCID,Reidy Mairead12345,Yu Yingjie6784,Mathieu Clelia12345,Nguyen Hung V.-T.9784ORCID,Coroller Thibaud P.534102,Lam Fred678411,Jarolim Petr5341213,Harvey Peter14784ORCID,Protti Andrea15161734,Nguyen Quang-De15161734,Johnson Jeremiah A.9784ORCID,Cremillieux Yannick1819202122,Tillement Olivier2324252622,Ghobrial Irene M.12345,Ghoroghchian P. Peter12345

Affiliation:

1. Department of Medical Oncology

2. Dana-Farber Cancer Institute

3. Boston

4. USA

5. Harvard Medical School

6. David H. Koch Institute for Integrative Cancer Research

7. Massachusetts Institute of Technology

8. Cambridge

9. Department of Chemistry

10. Department of Radiation Oncology

11. Clinical Scholar Program

12. Department of Pathology

13. Brigham and Women's Hospital

14. Department of Biological Engineering

15. Lurie Family Imaging Center

16. Department of Radiology

17. Dana-Farber Cancer Institute and Harvard Medical School

18. Institut des Sciences Moléculaires

19. Université de Bordeaux

20. UMR CNRS 5255

21. 33076 Bordeaux

22. France

23. Institut Lumière Matière

24. UMR 5306 Université Lyon1-CNRS

25. Université de Lyon

26. 69622 Villeurbanne Cedex

Abstract

Monitoring malignant progression and disease recurrence post-therapy are central challenges to improving the outcomes of patients with multiple myeloma (MM).

Funder

National Cancer Institute

Multiple Myeloma Research Foundation

Philippe Foundation

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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