<i>In situ</i>oxidative polymerization of platinum(<scp>iv</scp>) prodrugs in pore-confined spaces of CaCO<sub>3</sub>nanoparticles for cancer chemoimmunotherapy-Reference-Cited by-同舟云学术

In situoxidative polymerization of platinum(iv) prodrugs in pore-confined spaces of CaCO₃nanoparticles for cancer chemoimmunotherapy

Published:2023 Issue:25 Volume:14 Page:7005-7015
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wei Fangmian¹,Ke Libing¹,Gao Siyuan¹,Karges Johannes²^ORCID,Wang Jinquan³,Chen Yu¹^ORCID,Ji Liangnian¹,Chao Hui¹⁴^ORCID

Affiliation:

1. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510006, P. R. China

2. Faculty of Chemistry and Biochemistry, Ruhr-University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

3. Guangdong Provincial Key Laboratory of Biotechnology Drug Candidate, Guangdong Pharmaceutical University, Guangzhou, 510006, China

4. MOE Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, 400201, P. R. China

Abstract

Pt(iv)SS@CaCO3@Biotin can interact in cisplatin-resistant non-small lung cancer cells by a multimodal mechanism of action, triggering cell death by a combination of by apoptosis, ferroptosis, and immunogenic cell deathin vitroandin vivo.

Funder

National Natural Science Foundation of China

Science and Technology Program of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC02264A

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2. Molecular mechanisms of resistance and toxicity associated with platinating agents