Development of a multiple reaction monitoring (MRM) method based on high performance liquid chromatography/tandem mass spectrometry to analyze in vivo exposure profiles of complex herbal components independent of standards-Reference-Cited by-同舟云学术

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Development of a multiple reaction monitoring (MRM) method based on high performance liquid chromatography/tandem mass spectrometry to analyze in vivo exposure profiles of complex herbal components independent of standards

Published:2016 Issue:23 Volume:6 Page:19357-19371
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Xie Tong¹²³⁴⁵,Kang An⁶⁷³⁴⁵,Xu Jianya¹²³⁴⁵,Shen Cunsi¹²³⁴⁵,Zhao Xia¹²³⁴⁵,Di Liuqing⁶⁷³⁴⁵,Wang Shouchuan¹²³⁴⁵,Shan Jinjun¹²³⁴⁵

Affiliation:

1. Jiangsu Key Laboratory of Pediatric Respiratory Disease

2. Institute of Pediatrics

3. Nanjing University of Chinese Medicine

4. Nanjing 210023

5. China

6. Jiangsu Engineering Research Center for Efficient Delivery System of TCM

7. College of Pharmacy

Abstract

Exposure profiles of herbal componentsin vivoplay pivotal roles in pharmacodynamic and pharmacokinetic evaluation. The proposed MRM method has enabled profile exposure components, time and relative levels accurately.

Funder

National Natural Science Foundation of Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA25389F

Reference30 articles.

1. Translating slow-binding inhibition kinetics into cellular and in vivo effects

2. Drug–target residence time and its implications for lead optimization

3. Drug–target residence time: critical information for lead optimization

4. Chemicalome and Metabolome Matching Approach to Elucidating Biological Metabolic Networks of Complex Mixtures

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