Synthesis, conformational preferences, and biological activity of conformational analogues of the microtubule-stabilizing agents, (−)-zampanolide and (−)-dactylolide-Reference-Cited by-同舟云学术

Synthesis, conformational preferences, and biological activity of conformational analogues of the microtubule-stabilizing agents, (−)-zampanolide and (−)-dactylolide

Published:2019 Issue:5 Volume:10 Page:800-805
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Henry Jeffrey L.¹²³⁴,Wilson Matthew R.⁵⁶⁴,Mulligan Michael P.¹²³⁴,Quinn Taylor R.¹²³⁴,Sackett Dan L.⁷⁸⁹⁴,Taylor Richard E.¹²³⁴^ORCID

Affiliation:

1. The Warren Family Research Center for Drug Discovery and Development and the Department of Chemistry & Biochemistry

2. University of Notre Dame

3. Notre Dame

4. USA

5. Vertex Pharmaceuticals

6. Boston

7. Eunice Kennedy Shriver National Institute of Child Health and Human Development

8. National Institutes of Health

9. Bethesda

Abstract

Zampanolide and dactylolide are microtubule-stabilizing polyketides possessing potent cytotoxicity towards a variety of cancer cell lines.

Funder

National Institute of General Medical Sciences

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00164F

Reference49 articles.

1. Marine natural products: a new wave of drugs?

2. Natural products for cancer chemotherapy

3. Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

4. Marine Invertebrate Natural Products that Target Microtubules

5. Zampanolide, a new cytotoxic marcrolide from a marine sponge

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