Synthesis of an α-phosphono-α,α-difluoroacetamide analogue of the diphosphoinositol pentakisphosphate 5-InsP7-Reference-Cited by-同舟云学术

Synthesis of an α-phosphono-α,α-difluoroacetamide analogue of the diphosphoinositol pentakisphosphate 5-InsP7

Published:2019 Issue:7 Volume:10 Page:1165-1172
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Riley Andrew M.¹²³⁴⁵^ORCID,Wang Huanchen⁶⁷⁸⁹¹⁰,Shears Stephen B.⁶⁷⁸⁹¹⁰^ORCID,Potter Barry V. L.¹²³⁴⁵^ORCID

Affiliation:

1. Medicinal Chemistry and Drug Discovery

2. Department of Pharmacology

3. University of Oxford

4. Oxford OX1 3QT

5. UK

6. Inositol Signaling Group

7. Laboratory of Signal Transduction

8. National Institute of Environmental Health Sciences

9. National Institutes of Health

10. USA

Abstract

A synthetic, fluorinated analogue of 5-InsP₇binds to the kinase domain of PPIP5K2, suggesting new strategies for designing diphosphoinositol phosphate mimics.

Funder

Wellcome Trust

National Institute of Environmental Health Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00163H

Reference35 articles.

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4. Synthetic tools for studying the chemical biology of InsP8

5. Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate messengers

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