Synthesis and biological evaluation of (−)-kainic acid analogues as phospholipase D-coupled metabotropic glutamate receptor ligands
Author:
Affiliation:
1. Kosterlitz Centre for Therapeutics
2. Institute of Medical Sciences
3. University of Aberdeen
4. Scotland, UK
5. School of Medical Sciences
6. Department of Chemistry
7. C.N.R.-I.C.R.M.
Abstract
A “click” 4-(1,2,3-triazolyl)-kainate derivative and its biotinylated version potently increase stretch-induced afferent firing in muscle spindles, probably acting through a hitherto uncloned phospholipase D (PLD)-coupled mGlu receptor.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB02002B
Reference23 articles.
1. Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus
2. PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS
3. Towards a versatile synthesis of kainoids I: Introduction of the C-3 and C-4 substituents
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