Antimicrobial silver targets glyceraldehyde-3-phosphate dehydrogenase in glycolysis of E. coli-Reference-Cited by-同舟云学术

Antimicrobial silver targets glyceraldehyde-3-phosphate dehydrogenase in glycolysis of E. coli

Published:2019 Issue:30 Volume:10 Page:7193-7199
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wang Haibo¹²³^ORCID,Wang Minji⁴²³^ORCID,Yang Xinming¹²³,Xu Xiaohan¹²³,Hao Quan⁵²⁶,Yan Aixin⁴²³^ORCID,Hu Menglong⁵²⁶,Lobinski Ryszard⁷⁸⁹¹⁰¹¹,Li Hongyan¹²³,Sun Hongzhe¹²³^ORCID

Affiliation:

1. Department of Chemistry

2. The University of Hong Kong

3. P. R. China

4. School of Biological Sciences

5. School of Biomedical Sciences

6. China

7. CNRS/University of Pau

8. Institute of Analytical and Physical Chemistry for the Environment and Materials

9. IPREM-UMR5254

10. 64053 Pau

11. France

Abstract

We report for the first time that antimicrobial Ag⁺ targets the glycolytic pathway through inhibiting the key enzyme of GAPDH.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC02032B

Reference55 articles.

1. Antimicrobial activity of metals: mechanisms, molecular targets and applications

2. Metal-based antimicrobial strategies

3. Is Silver the Ultimate Antimicrobial Bullet?

4. Give silver a shine

5. Nanobio Silver: Its Interactions with Peptides and Bacteria, and Its Uses in Medicine

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