Synthesis and bioactivity of fused- and spiro-β-lactone-lactam systems-Reference-Cited by-同舟云学术

Synthesis and bioactivity of fused- and spiro-β-lactone-lactam systems

Published:2017 Issue:25 Volume:15 Page:5373-5379
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Josa-Culleré Laia¹²³⁴⁵^ORCID,Towers Christopher⁶³⁷⁴⁵,Willenbrock Frances⁶³⁷⁴⁵,Macaulay Valentine M.⁶³⁷⁴⁵,Christensen Kirsten E.¹²³⁴⁵,Moloney Mark G.⁶³⁷⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Chemistry Research Laboratory

3. University of Oxford

4. Oxford

5. UK

6. Department of Oncology

7. Old Road Campus Research Building

Abstract

Fused systems are formed preferentially, under standard conditions, but spiro systems are accessible only when the formation of the fused system is blocked and with careful optimisation of reaction conditions.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB01148B

Reference22 articles.

1. The Oxazolomycins: A Structurally Novel Class of Bioactive Compounds

2. Total Synthesis of Oxazolomycins

3. Salinosporamide Natural Products: Potent 20 S Proteasome Inhibitors as Promising Cancer Chemotherapeutics

4. The structural requirements for inhibition of proteasome function by the lactacystin-derived ?-lactone and synthetic analogs

5. THE PROTEASOME AND PROTEASOME INHIBITORS IN CANCER THERAPY

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