Revealing electronic features governing hydrolysis of cephalosporins in the active site of the L1 metallo-β-lactamase-Reference-Cited by-同舟云学术

Revealing electronic features governing hydrolysis of cephalosporins in the active site of the L1 metallo-β-lactamase

Author:

Levina Elena O.¹²³⁴⁵^ORCID,Khrenova Maria G.¹²³⁶²^ORCID,Astakhov Andrey A.¹²³⁷⁸,Tsirelson Vladimir G.¹²³⁹²^ORCID

Affiliation:

1. Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences

2. Moscow

3. Russia

4. Moscow Institute of Physics and Technology

5. Dolgoprudny

6. Lomonosov Moscow State University

7. Joint Institute for Nuclear Research

8. Dubna

9. Mendeleev University of Chemical Technology of Russia

Abstract

Combination of QM/MM and modern bonding descriptors explains different reactivity of cephalosporins in the active site of the L1 metallo-β-lactamase.

Funder

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

Reference78 articles.

5. R. F. W.Bader , Atoms in molecules. Quantum Theory , Clarington Press , Oxford , 1994

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