Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation

Author:

Carrascosa Laura G.123,Sina Abu Ali Ibn123,Palanisamy Ramkumar123,Sepulveda Borja45,Otte Marinus A.45,Rauf Sakandar123,Shiddiky Muhamad J. A.123,Trau Matt12367

Affiliation:

1. Australian Institute for Bioengineering and Nanotechnology (AIBN)

2. The University of Queensland

3. Brisbane, Australia

4. Catalan Institute of Nanoscience and Nanotechnology (ICN2)

5. Campus UAB 08193 Bellaterra, Spain

6. School of Chemistry and Molecular Biosciences

7. University of Queensland

Abstract

DNA regional methylation can be detected in real-time and label-free using surface plasmon resonance biosensing coupled to molecular inversion probe based amplification.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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