A sequentially activated bioluminescent probe for observation of cellular H2O2 production induced by cysteine-Reference-Cited by-同舟云学术

A sequentially activated bioluminescent probe for observation of cellular H2O2 production induced by cysteine

Published:2021 Issue:78 Volume:57 Page:10015-10018
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Ma Kaiqing¹^ORCID,Yue Yongkang¹,Zhao Lingling¹,Chao Jianbin²^ORCID,Yin Caixia¹^ORCID

Affiliation:

1. Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Key Laboratory of Materials for Energy Conversion and Storage of Shanxi Province, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China

2. Research Institute of Applied Chemistry, Shanxi University, Taiyuan 030006, China

Abstract

We report herein a caged luciferin probe Cy-Hy as a sequentially activated probe to selectively and sensitively sense l-Cys and H2O2, utilizing the present probe, the cellular excess l-Cys induced H2O2 up-regulation was observed for the first time in the living MDA-MB-231 cells.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D1CC04015D

Reference30 articles.

1. Chemical Design and Synthesis of Functionalized Probes for Imaging and Treating Tumor Hypoxia

2. Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

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