Structure and dynamics of the proton-selective histidine and the gating tryptophan in an inward rectifying hybrid influenza B and A virus M2 proton channel-Reference-Cited by-同舟云学术

Structure and dynamics of the proton-selective histidine and the gating tryptophan in an inward rectifying hybrid influenza B and A virus M2 proton channel

Published:2024 Issue:30 Volume:26 Page:20629-20644
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Pankratova Yanina¹^ORCID,McKay Matthew J.¹,Ma Chunlong²,Tan Haozhou³,Wang Jun³^ORCID,Hong Mei¹^ORCID

Affiliation:

1. Department of Chemistry, Massachusetts Institute of Technology, 170 Albany Street, Cambridge, MA 02139, USA

2. Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, 85721, USA

3. Department of Medicinal Chemistry, Rutgers University, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA

Abstract

Solid-state NMR spectra of a mutant influenza B M2 protein shine light on how charged residues near a tryptophan impact proton shuttling by a key histidine, thus regulating the proton conduction direction in this family of proton channels.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CP/D4CP01648C

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