Dual inhibitors of LSD1 and spermine oxidase
Author:
Affiliation:
1. Department of Drug Discovery and Biomedical Sciences
2. Medical University of South Carolina
3. Charleston
4. USA
5. Sidney Kimmel Comprehensive Cancer Center
6. Johns Hopkins School of Medicine
7. Baltimore
Abstract
Dual inhibitors of LSD1 and SMOX, with no activity against N1-acetylpolyamine oxidase (PAOX).
Funder
National Institutes of Health
Samuel Waxman Cancer Research Foundation
Publisher
Royal Society of Chemistry (RSC)
Subject
Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/MD/C8MD00610E
Reference28 articles.
1. Prominent role of histone lysine demethylases in cancer epigenetics and therapy
2. Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes
3. Novel Oligoamine Analogues Inhibit Lysine-Specific Demethylase 1 and Induce Reexpression of Epigenetically Silenced Genes
4. Structure–activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures
5. (Bis)urea and (Bis)thiourea Inhibitors of Lysine-Specific Demethylase 1 as Epigenetic Modulators
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