Detoxification of amyloid β fibrils by curcumin derivatives and their verification in a <i>Drosophila</i> Alzheimer's model-Reference-Cited by-同舟云学术

Detoxification of amyloid β fibrils by curcumin derivatives and their verification in a Drosophila Alzheimer's model

Published:2022 Issue:15 Volume:58 Page:2576-2579
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Utomo Rohmad Yudi¹,Sugie Atsushi²,Okada Satoshi¹³⁴^ORCID,Miura Kazuki¹³^ORCID,Nakamura Hiroyuki¹³^ORCID

Affiliation:

1. School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama, Kanagawa 226-8503, Japan

2. Brain Research Institute, Niigata University, 757, Ichiban-cho, Asahimachidori, Chuo-ku, Niigata 951-8585, Japan

3. Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama, Kanagawa 226-8503, Japan

4. JST, PRESTO, 4259 Nagatsuta, Midori, Yokohama, Kanagawa 226-8503, Japan

Abstract

Curcumin derivatives B and N developed as disaggregation agents of amyloid β (Aβ) fibrils significantly rescued locomotion dysfunction in an Aβ-expressing Drosophila model of Alzheimer's disease.

Funder

Niigata University

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D1CC07000B

Reference35 articles.

1. Drug development in Alzheimer’s disease: the path to 2025

2. The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

3. Aducanumab produced a clinically meaningful benefit in association with amyloid lowering

4. Immunotherapy for Alzheimer’s disease: hoops and hurdles

5. Molecular mechanisms of amyloid disaggregation

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